Biosynthesis and bioactivities of metal nanoparticles mediated by Helichrysum aureonitens

نویسندگان

چکیده

Abstract Biosynthesis of nanoparticles is the preferred route for fabrication biocompatible and cheaper drugs. In this study, extract major secondary metabolite from Helichrysum aureonitens , 3,5-dihydroxy-6,7,8-trimethoxyflavone, were used to synthesize silver zinc oxide nanoparticles. Spectroscopic microscopic techniques confirmed formation The flavone alone showed higher DPPH radical scavenging ability (IC 50 = 487.1 μg mL −1 ) relative control, butylated hydroxytoluene. addition, synthesized using had ferric reducing potential (Fe 3+ Fe 2+ compared other test samples. cytotoxic activity plant extract, flavone, their biosynthesized was also investigated MTT assay against cancerous MCF-7 (breast adenocarcinoma) A549 (human lung adenocarcinoma)), non-cancerous HEK293 embryonic kidney) cell lines. decreased viability 68.6 without being HEK293, even at high concentrations. Silver significantly moderately but induced death low This study provides a green synthesis confirms therapeutic effectiveness H. thereby validating its use in ethnomedicine.

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ژورنال

عنوان ژورنال: Journal of Analytical Science and Technology

سال: 2022

ISSN: ['2093-3134', '2093-3371']

DOI: https://doi.org/10.1186/s40543-022-00316-7